The Medical Faculty of the University of Zurich is an international leader in biomedical research. The laboratories of the involved research groups are equipped with an excellent infrastructure to study single cell behaviour and the assembly and evaluation of 3D tissue constructs, as well as developing novel autologous dermo-epidermal skin substitutes (full thickness skin analogues). Soft and hard tissue animal models are available. Access to FACS and sorting, time-lapse confocal microscopy, uCT and MRI are available at core facilities The groups have significant expertise in the isolation and characterization of fetal and adult human stem/progenitor cells, skin cells and the design of novel biomaterials for studying cell-material interactions and growth factor delivery. Novel, fully synthetic, biomimetic, growth factor delivery matrices have recently been implemented for the assembly of tissue-like constructs under fully defined conditions in vitro using layer-by-layer and printing approaches.
The Laboratory for Cell and Tissue Engineering of the Department of Obstetrics has specialized in the development of biological therapies for hard-to-heal wounds such as skin ulcers, ischemic or infarcted heart and limbs, and the repair or prevention of fetal membrane rupture using Experimental Tissue Engineering.
The Tissue Biology Research Unit (TBRU) is the experimental research laboratory of the Department of Surgery of the University Children's Hospital Zurich, Switzerland. The research unit focuses on the development of autologous dermo-epidermal skin substitutes (full thickness skin analogues) that can be used clinically to cover skin defects of any origin.